Molecular Biology / Biochemistry Scientist

Bay Area, CA

Prellis Biologics employs proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries, camelid antibody libraries, in vitro human immunogenicity screening, and in vitro human tumor/lymph node cocultures for therapeutic screening. Prellis’ ability to print and culture healthy human tissue provides it with unique opportunities for generating and evaluating next-generation human therapeutics.

Prellis Biologics is seeking a highly motivated individual to join our research team and help develop our next-generation antibody discovery technology. The role will be integrated with our cell biology teams and will require background knowledge in antibody discovery/characterization platforms, particularly with respect to monoclonal antibody expression and development. 

The ideal candidate will have previous hands-on experience with monoclonal antibody development, including plasmid design, transient and stable mammalian protein expression systems, biochemical characterization of recombinant proteins, cell line culture, and a proven track record of applying bioinformatic analysis for drug discovery. Meticulous attention to detail, proficient reasoning, and problem-solving skills are cornerstones for a successful candidate.

Job responsibilities include:

• Developing and implementing HT small scale monoclonal antibody expression processes

• Characterizing biological and biochemical properties of monoclonal antibodies

• Serving as a subject matter expert in recombinant protein production to different cross-functional teams

Preferred qualifications:

• MS with 10+ years or PhD with 5+ years of relevant hands-on experience (preferably in industry) in biochemistry, molecular biology, protein engineering or related field

• Mastery of techniques for small-scale protein expression in mammalian cells

• Experienced in troubleshooting and optimizing expression/purification conditions

• Familiarity with protein expression in E. coli or other hosts is a plus

• Direct experience with high-throughput expression/purification systems is a plus

• Mastery of techniques for protein purification by chromatography-based methods (affinity, ion exchange, size-exclusion, etc.)

• Skilled in ELISA, SPR, Octet, and FACS-based assays towards antibody characterization

• Prior experience characterizing proteins via standard biochemical techniques (SDS-PAGE, western blots, thermal melts, stability, and activity assays)

• Direct experience with single cell sequencing technologies is a plus

• Direct experience with affinity maturation techniques is a plus

• Detail-oriented, highly organized, strong in time management, and teamwork are essential

• Excellent interpersonal, communication and presentation skills able to positively influence project direction and strategy

• Self-starter and ability to multitask

Please send your resume to careers@prellisbio.com to apply.

Prellis is committed to the principles of equal employment opportunity. Applicants are considered for all positions without regard to race, sex, sexual orientation, color, religion, national origin, age, and disability (so long as such disability can be reasonably accommodated) or any other status protected by applicable law. Prellis encourages all qualified applicants to apply.