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Scientist, Chemistry

Bay Area, CA

Scientist, Chemistry

Prellis Biologics employs 2-photon holography to print human tissues and organs in real time. Current applications of our platform include printing of lymph node organoids, which we are using to generate in vitro human antibody libraries, camelid antibody libraries, in vitro human immunogenicity screening, human primary tumor/lymph node co-cultures for therapeutic screening, and vaccine R&D. Prellis’ ability to print and culture healthy human tissue provides it with unique opportunities for generating and screening next generation human therapeutics.

Prellis Biologics is seeking a Chemist to drive the development of next-generation, biocompatible ink formulations to 3D print tissue scaffolds using 2-photon holography. This role requires polymer synthesis, formulation, and characterization experience. The ideal candidate will be comfortable working in the laboratory and with Prellis printers to test ink formulations. 

Key Responsibilities:

  • Drive the development of new polymer formulations (inks) to 3D print tissue scaffolds using 2-photon polymerization on Prellis printers

  • Apply your understanding of polymer structure-property relationships to optimize ink chemistry to deliver printed scaffolds that meet the requirements of new workflows and products on the roadmap

  • Contribute to the generation of intellectual property for new inks and printed scaffolds

  • Characterize ink raw materials, ink formulations, and printed scaffolds using appropriate analytical methods; this will sometimes involve working with external laboratories to perform measurements

  • Collaborate with internal teams such as Biology and Manufacturing to monitor the performance of inks and printed scaffolds

  • Troubleshoot issues with inks and scaffolds

  • Define quality control (QC) metrics for inks and printed scaffolds. Develop tests to quantitatively measure those metrics

  • Document standard operating procedures (SOPs) to formulate, print, and QC new inks

  • Perform technology transfer with Manufacturing

Skills and Experience:

  • Ph.D. in Chemistry, Chemical Engineering, or Polymer Engineering with a strong academic record

  • Research experience with polymer chemistry and characterization

  • Outstanding M.S. candidates with relevant industry experience will be considered

  • Hands-on experience with polymer synthesis, formulation, and characterization

  • Experience with photopolymerizable hydrogels and free-radical polymerization is desired

  • 3D printing experience is a plus

  • Hands-on experience with analytical techniques such as NMR, FTIR spectroscopy, mass spectrometry, liquid chromatography (LC), UV-Vis spectroscopy, and fluorescence spectroscopy

  • Experience with characterization techniques for polymers and viscoelastic materials such as rheometry, differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and gel permeation chromatography (GPC)

  • Rigorous scientist who designs and conducts careful experiments, maintains detailed records in laboratory notebooks, and develops robust, transferrable processes

  • Surface and interfacial chemistry experience – particularly with the chemical modification of surfaces for cell culture

  • Familiarity with design of experiments (DOE) and statistical analysis

  • Experience with cell culture and familiarity with basic molecular and cell biology techniques

  • Strong written and oral communication skills

  • Able to thrive in a dynamic, collaborative start-up environment

Please send your resume to to apply.

Prellis is committed to the principles of equal employment opportunity. Applicants are considered for all positions without regard to race, sex, sexual orientation, color, religion, national origin, age, and disability (so long as such disability can be reasonably accommodated) or any other status protected by applicable law. Prellis encourages all qualified applicants to apply.