Organoids are biocompatible structures that hold your precious cells in place with an oxygen permeable 3D scaffold, guaranteeing your 3D tissue culture will work every time.
No more waiting for spheroid growth.
In less than 24 hours
Begin testing 3D cell responses
Transplant into an animal model
Induce cell differentiation in a 3D scaffold
Why screen therapeutics in 3D cell culture?
More accurate drug screening results
Differential cell gene expression relative to 2D
Better replicates the in vivo environment
Improved human to animal translation
When you have complexity, like in [conventional] organoids or in animals – you increase variability. So we think we can reduce variability using the [Prellis] organoids especially going from the organoid to in vivo. The structures are also more consistent, so less variability from that perspective too. Less variability means quicker, with less cost and more tests – to results.
Marcus Muench, PhD
Associate Adjunct Professor
Small 3D tissues. Huge R&D potential.
Cell Lines: HCT116, A549
Primary Immune Cells
Primary Fetal Liver
use with over 15 primary cell types
3D Cell Culture
Microfluidics Set Ups
Long-term 3D Tissue Growth (4 wks)
Developmental Biology Studies
Cell-Cell Interaction Studies
Multi-cellular Organism Studies
compatible with a variety of assays
The issue of vascularization of the organoid models is key. The traditional organoids are not healthy, because they have no vasculature, which is what gets nutrients through the structure. Really it is the tissue, just cells piled on to each other [and] in the center of that pile they have no nutrients, no oxygen – and they die. So the idea is that the Prellis structure, with the vasculature, keeps it from dying.
Jennifer Erwin, PhD
Johns Hopkins University
Application Example: Animal Transplant
Vascular organoid seeding
3 weeks post-tumor transplant
in vitro vascularization of organoid scaffold